A growth factor for hepatocytes is inactivated by sub-lethal gamma-irradiation in vivo or in vitro.

نویسندگان

  • G G Skouteris
  • M G Ord
  • L A Stocken
چکیده

Serum from partially hepatectomized rats promoted DNA synthesis in primary adult rat hepatocyte cultures. If the rats had been exposed to sub-lethal gamma-irradiation immediately following operation or if their serum, collected at 3 h, was exposed to irradiation in vitro, the growth-promoting activity was destroyed. Prostaglandin E2 also stimulated DNA synthesis in the cultures; if PGE2 was irradiated in serum from intact or partially hepatectomized rats its growth-promoting activity was markedly diminished.

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عنوان ژورنال:
  • FEBS letters

دوره 245 1-2  شماره 

صفحات  -

تاریخ انتشار 1989